NFL DFS Late Slate Picks for Week 10

Ok you DFS degenerates, we have three games in the Late Slate. That gives us six teams to choose from and one game with the highest over/under of the week. I can feel the fantasy goodness now. If you need to feel better about your season, or just your Week 10, read this, go and create a Late Slate lineup and enjoy the fun.

This is the Week 10 Late Slate.

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Week 10 NFL DFS Late Slate Picks

The Games

Quarterbacks

Brock Purdy, San Francisco 49ers

The Niners play the Cowboys in Week 10. Dallas gives up the sixth-most fantasy points to quarterbacks weekly. In Week 9, Purdy threw for 232 yards and two touchdowns despite missing key receivers. We have a quarterback who will throw the ball in a nice matchup that looks like a shootout. The over/under is 56 points. Stack up those Niners like pancakes in Week 10.

Dak Prescott, Dallas Cowboys

Go to the other side of the ball in the Late Slate, and you have Prescott. He threw for 335 yards and two touchdowns last week, with CeeDee Lamb accounting for 195 yards and one score. Prescott-Lamb is a straightforward tournament foundation, with a 49ers pass catcher as a possible return player. This is a production-and-game-environment play: the total creates opportunities for both offenses without guaranteeing every possession becomes a touchdown.

Matthew Stafford, Los Angeles Rams

Stafford gives you a less expensive tournament play against an Arizona defense, allowing the second-most fantasy points to opposing teams’ quarterbacks. He’s best used in a lineup that benefits from Los Angeles scoring through the air, paired with a healthy tight end or confirmed starting receiver. With Puka Nacua and Davante Adams sidelined, receiving roles matter more than a familiar name on last month’s depth chart.

Running Backs

Christian McCaffrey, San Francisco 49ers

McCaffrey is a priority premium consideration against a Dallas defense giving up the fifth-most running back fantasy points. Last week brought 18 carries and two receptions, with both a rushing and receiving touchdown. His volume and opportunity can pay off through several game scripts: sustained rushing work if San Francisco leads or catches if the game becomes a back-and-forth affair. I am paying up in Week 10.

Javonte Williams, Dallas Cowboys

Williams brings one of the clearest volume cases on this slate. The Reedy Volume Report records 25, 25, and 24 touches over his last three games; 74 in total. He also drew five targets in Week 9 and played 72% of Dallas’ offensive snaps. Williams also appears to be the only healthy running back on the Cowboys right now. If you do a Niners stack, you can use Williams to run it back.

Zach Charbonnet, Seattle Seahawks

Charbonnet carried 16 times for 77 yards last week and now faces a Raiders defense, allowing the third-most running back fantasy points weekly. Seattle is a 6.5-point favorite, setting up a game where the Seahawks should lead the entire way and giving Charbonnet a path to rushing opportunities.

Kyren Williams, Los Angeles Rams

Williams belongs in the tournament discussion with Los Angeles favored by 9.5 points. A Rams lead would support continued rushing work, and with all the injuries to the receiving group, there is another reason to feel good about his passing-game involvement. Blake Corum’s role means we should price Williams as part of a shared backfield rather than assume every carry is his. I think both Corum and Williams will produce in Week 10.

Wide Receivers

CeeDee Lamb, Dallas Cowboys

Lamb produced a 10-catch, 195-yard, one-touchdown gem last week on 16 targets. He has reached double-digit targets in four straight games. Volume is king, and Lamb brings us weekly volume. Easy to say, play Lamb, especially in a shootout, as we expect for Sunday’s game.

Jaxon Smith-Njigba, Seattle Seahawks

Smith-Njigba is another high-end wide receiver in a good matchup. The Raiders are up, and they allow the 10th-most fantasy points to opposing teams’ wide receivers. Jaxon saw 10 targets last week. Seattle expects Drew Lock to start, so Lock’s ability to play through his elbow and oblique issues remains part of the decision. Smith-Njigba is a tournament play only right now.

Keenan Allen, San Francisco 49ers

Allen is new to the Niners. Starting wide receivers tend to get fantasy points in the Niners’ offense. This week Allen plays against a Dallas defense that allows the sixth-most wide receiver fantasy points weekly. The risk is that we don’t know what Allen’s role will be, especially in his first game. I’ll still play him on DraftKings because it is PPR.

Other receivers to consider

• Ryan Flournoy: He brings value if Dallas remains short-handed. His full Week 9 route participation is the reason to investigate him; the final receiver rotation determines whether that opportunity continues.
• Jordan Watkins: Ran routes on 87% of San Francisco’s dropbacks last week and caught four passes for 86 yards and a touchdown. The routes are encouraging, but four targets and Allen’s arrival keep this a tournament role-and-price decision.
• Konata Mumpfield and Tutu Atwell: Both bring salary relief for us in the depleted Rams receiver room.

Tight Ends

George Kittle, San Francisco 49ers

Kittle led San Francisco with seven targets and 76 air yards last week. Four catches for 58 yards underscored that opportunity, showing why we examine volume before chasing box scores. He is a priority stacking candidate with Purdy in the slate’s highest over/under.

Brock Bowers, Las Vegas Raiders

Bowers remains the top tight end option because of his concentration of opportunity. Target-tree data shows a massive 29% season target share, with 40% in Week 8 and 25% in Week 9. He followed that involvement with seven catches for 111 yards and a touchdown last week. Fernando Mendoza’s debut is a little scary, but it does not erase Bowers’ role. He is a tournament option on his own or as a Raiders return player in a Seattle-focused construction.

Trey McBride, Arizona Cardinals

McBride’s recent usage report shows approximately 9.7 targets per game and 90% snap participation across Weeks 7-9. He’s also the top option in his offense. Apparently, desert air agrees with tight ends. Treat him as a tournament consideration whose ceiling improves if Arizona sustains drives and Beck repeatedly finds his established receiving options. Michael Wilson’s season-ending neck injury removes another established target from Arizona’s receiving group. This could mean even more targets for McBride.

AJ Barner, Seattle Seahawks

Barner offers access against a Raiders defense, allowing the fifth-most fantasy points to opposing teams’ tight ends. They allow 6.6 catches, 56 yards, and 0.9 touchdowns per game. His 13.5% target share shows his receiving involvement at an affordable price. A 5.4% air-yard share suggests shorter catches and scoring opportunities will drive the return.

Tyler Higbee and Colby Parkinson, Los Angeles Rams

Arizona gives up the eighth-most tight end fantasy points weekly, and Los Angeles has a substantial receiving workload to redistribute. Nacua accounted for 42.3% of Stafford’s targets since Week 7. Participation was 80% of snaps for Higbee and 73% for Parkinson last week, showing both can play together. Those snaps do not prove receiving routes.

Defenses

Los Angeles Rams

Arizona is turning to Beck for his first NFL start while dealing with injuries at center, guard, and tackle. Los Angeles is favored by 9.5 points. We have a rookie quarterback with a dinged-up offensive line. Not sure there’s a better case than this.

Seattle Seahawks

The Seattle defense also gets to play against an inexperienced quarterback. This is Mendoza’s first NFL start. Potential returns along the Seahawks’ defensive front would strengthen that argument, so monitor Leonard Williams and the other defensive injury updates. The Seahawks will pressure Mendoza, and we should see sacks and turnovers here.

Stacking the Late Slate

• Purdy + Kittle, with Lamb returning: An established receiving role on each side of the highest-total game.
• Prescott + Lamb, with McCaffrey or Kittle returning: Buy Dallas’ repeated target volume and a productive San Francisco counterpart.
• Stafford + a confirmed Rams receiving option: A lower-cost tournament approach if Los Angeles’ touchdowns come through the air.
• Charbonnet + Seahawks D/ST: A construction that benefits if Seattle builds a lead, sustains rushing work and pressures the rookie quarterback.

These are construction ideas, not completed salary-cap lineups. A return player is useful when the game script supports it; it is not mandatory in every stack.

Make sure to check out all of our Week 10 Fantasy Football Rankings and Analysis!