NFL DFS Late Slate Picks Week 15

Welcome back, DFS Degenerates. Week 15 is the start of the fantasy playoffs for season-long formats, but for us? Every week is playoff week. Every slate is a fresh shot at glory. So, if your redraft squad got bounced, don’t pout, DFS is still here to wrap you in its warm, data-driven embrace: no tilt, no season-long heartbreak, just a big hug. Week 15 NFL DFS is upon us.

And speaking of chaos… if you didn’t know, I’ve been fighting a cough for basically the entire year of 2025. At this point, I should have a shredded six-pack from all the hacking, like some wheezing Greek god, but no. Not even close. The only thing I’m chiseling is DFS lineups.

So, let’s dive in, let me clear my throat, and attack this late slate as if it owes us money.

More Week 15 Fantasy Football Fun!: | Sneaky Starts | Fantasy Football Waiver Wire | Weekly Sleepers & Streamers | Starts & Sits | Skrip’s Week Winners | NFL DFS | NFL Player Props | IDP Analysis | Bold Predictions | Survivor Picks | NFL Injury Report | Dynasty Trade Targets | Weekly Rankings | Dynasty Risers and Fallers

Week 15 NFL DFS Late Slate Picks

Quarterbacks

Matthew Stafford, Los Angeles Rams

Matthew Stafford has tossed multiple touchdowns in seven straight games and leads the league with 35 passing scores. He’s been automatic. Now he gets the Lions, a defense allowing the fifth-most fantasy points to quarterbacks and an average of two passing TDs per game. Sometimes the matchup and the player align perfectly; this is one of those times.

$7,000 on DraftKings
$8,300 on FanDuel

Brock Purdy, San Francisco 49ers

Brock Purdy is healthy again, and so are his receivers. He’s thrown multiple touchdowns in two of his last three games, and now he draws a Titans defense that has allowed multiple QB passing scores in six of the previous seven. The matchup is soft, the weapons are back, and I’m Purdy sure he’s set up for a big Week 15.

$6,200 on DraftKings
$7,500 on FanDuel

Running Backs

Devon Neal, New Orleans Saints

The Saints play the Panthers in Week 15. The Panthers give up the 9^th most fantasy points to opposing teams’ running backs. He has had 17 or more touches over the past two games and is looking like a high-volume option in a good match-up for Week 15. In Week 14, he managed 84 total yards and a touchdown. We should see similar numbers for Neal in Week 15. Nothing punny for me to say here.

$5,300 on DraftKings
$6,100 on FanDuel

RJ Harvey, Denver Broncos

Over the past two games, Harvey has grown his role in the Broncos’ offense. He has scored two touchdowns in one of those games and surpassed 100 yards and scored another touchdown in the other. The matchup will be challenging in Week 15 against the Packers, but he should see the volume to carry him.

$6,000 on DraftKings
$6,600 on FanDuel

Chuba Hubbard, Carolina Panthers

In his last game against a tough Rams defense, Hubbard managed 19 total touches, 124 total yards, and a touchdown. He faces a Saints defense that is not nearly as imposing in Week 15. He also led the Panthers in running back snaps with 59%. It appears he has taken over the Panthers’ backfield yet again. Hubba, hubba, Chuba looks good in Week 15.

$4,600 on DraftKings
$5,900 on FanDuel

Running Back Notes: Aaron Jones has a great match-up this week but simply hasn’t been producing. So, if you are daring, he is another option in a good spot in Week 15.

Wide Receivers

Puka Nacua, Los Angeles Rams

The Rams get the Lions in Week 15, and we’ve already covered how vulnerable Detroit is through the air. They allow the second-most fantasy points to opposing wide receivers, and this matchup carries a 55-point total, the highest on the main slate. It doesn’t get much juicier for Puka Nacua. He’s already sitting at 93 catches, 1,186 yards, and six touchdowns, proving he’s one of the league’s elites. So, what do you do when one of the best receivers in football walks into a dream matchup like this? You play him, obviously.

$8,700 on DraftKings
$9,700 on FanDuel

Jameson Williams, Detroit Lions

If you decided to stack with Stafford and Puka, you can run it back with Jamo. The matchup is middling (15th), but his role is expanding. He has double-digit fantasy scores in five out of the last six games. With the shoot-out that is looming here, plugging in Williams is probably a good thing.

$6,100 on DraftKings
$6,300 on FanDuel

Jayden Reed, Green Bay Packers

Reed eased back into action in Week 14, posting 4 receptions for 31 yards and adding 22 more on the ground. Nothing flashy, but precisely what you want to see from a player returning from injury, usage. The Packers immediately plugged him back into that hybrid role we love, giving him targets and designed touches that keep his floor FLEX-safe and his ceiling enticing.

$4,500 on DraftKings
$5,900 on FanDuel

Jauan Jennings, San Francisco 49ers

Jennings has quietly become one of the most reliable touchdown machines in fantasy, finding the end zone in four of his last five games. He’s not flashy, but he’s steady—operating as the 49ers’ trusted chain-mover who consistently pops up where it matters most: the red zone. Now he gets a Titans defense that ranks 9th in late-season matchups for opposing wide receivers, making this a prime spot to ride the hot hand. If you need a Week 15 plug-and-play with touchdown upside, Jennings is firmly on the radar.

$5,200 on DraftKings
$6,200 on FanDuel

Tight Ends

Tyler Warren, Indianapolis Colts

It appears Philip Rivers will be starting at quarterback for the Colts in Week 15 against the Seahawks. The only pass-catcher I see who would completely benefit the Colts is Warren. Seattle gives up the fourth most fantasy points to tight ends. Rivers probably can’t throw the ball very far. This situation reeks of tight-end volume.

$4,700 on DraftKings
$5,900 on FanDuel

George Kittle, San Francisco 49ers

Kittle has 67 or more yards in four straight games. The Niners are playing the Titans at home and need a win. I can see Kittle scoring a touchdown in this one as the Titans have given up three touchdowns to tight ends over the past two games.

$5,400 on DraftKings
$6,500 on FanDuel

Juwan Johnson, New Orleans Saints

The Saints play the Panthers in Week 15. They also played the Panthers in Week 10. In that game, Johnson saw four targets. He caught all four of those for 92 yards and a touchdown. Juwan is the secondary target for the Saints in a nice matchup this week. Looks like a big Johnson week.

$3,700 on DraftKings
$5,300 on FanDuel

Defense

San Francisco 49ers

The 49ers draw the Titans in Week 14, and Tennessee still allows the third-most fantasy points to opposing defenses. Yes, the Titans have shown recent improvement, but San Francisco is rested after a bye and playing at home. This unit should come out fresh, fast, and ready to make life miserable for Tennessee.

$4,000 on DraftKings
$4,700 on FanDuel

Make sure to check out all of our Week 15 Fantasy Football Rankings and Analysis!