2025 Fantasy Football: Week 10 Quarterback Rankings

The leaves are falling, the air smells like pumpkin pie, and fantasy managers everywhere are gathering around the table, hoping their quarterbacks serve up something better than dry turkey. It’s Thanksgiving season — time for gratitude, family, food, and, of course, those inevitable moments when fantasy football feels like Lucy pulling the football away from Charlie Brown. You line up a perfect matchup, ready to score big… and whiff.

But there’s always another week to kick again — and this one’s filled with opportunity. That’s why we’re diving into the Week 10 Fantasy Football QB Rankings, where we break down the top fantasy quarterbacks, sneaky streamers, and matchups to feast on.

Before we carve into Week 10’s fantasy quarterback rankings, let’s look back at who brought the feast last week — and who left us hungry.

More Week 10 Fantasy Football Fun!: | Sneaky Starts | Fantasy Football Waiver Wire | Weekly Sleepers & Streamers | Starts & Sits | Skrip’s Week Winners | NFL DFS | NFL Player Props | IDP Analysis | Bold Predictions | Survivor Picks | NFL Injury Report | Dynasty Trade Targets | Weekly Rankings | Dynasty Risers and Fallers

🥧 Week 9 Recap: Feast and Famine

Last week, I was higher on Caleb Williams than most — and he delivered in style, finishing as QB1 with a whopping 36.7 fantasy points. The sophomore refuses to slump, proving he’s not just hype; he’s a weekly difference-maker.

Joe Flacco nearly stole the show with 32.7 points, going from injury risk to QB2 hero in one of the wildest turns of the season. Josh Allen did his usual thing, finishing QB3 with 28.8 points, while Justin Herbert (28.7) and Sam Darnold (28.2) rounded out the top five.

Meanwhile, Patrick Mahomes cooled off dramatically in what should’ve been a smash matchup against Allen and the Bills — producing just 11.5 fantasy points in a dud that left fantasy managers shaking their heads. Jayden Daniels managed 16.2 points before exiting early with a nasty arm injury; expect Marcus Mariota to take over for at least the next month, maybe longer if Washington falters.

And then there’s Dak Prescott, who had the juiciest home matchup against Arizona — and still finished as a low-end QB2 (16.4). Fantasy managers everywhere felt like Charlie Brown watching Lucy smirk.

Now, onto Week 10 Fantasy Football Quarterback Rankings — where new heroes will rise, and others may once again have the football pulled away.

🔥 High-Total Games (Shootout Potential – 47+)

These matchups are bursting with fantasy fireworks — perfect for stacking quarterbacks and unleashing some Halloween-week offense.

Buffalo Bills @ Miami Dolphins — O/U 49.5 (MIA -9.5)

Thanksgiving’s about generosity, and Josh Allen keeps handing out fantasy points like dinner rolls. He’s a locked-in top-three QB play again, facing a shaky Miami defense.
On the other sideline, Tua Tagovailoa has been cold — just 9.5 points last week — and now faces a ferocious Buffalo front. He’s a low-end QB2, better left on the Thanksgiving leftovers list.

Detroit Lions @ Washington Commanders — O/U 49.5 (DET -8.5)

Jared Goff continues to serve up steady fantasy production, which should continue this week against a reeling Commanders team. He’s a safe-floor QB1 play this week.
For Washington, Marcus Mariota steps in for the injured Jayden Daniels — his rushing ability keeps him in Superflex consideration, but temper expectations against a tough Detroit defense.

Baltimore Ravens @ Minnesota Vikings — O/U 49.0 (BAL -4)

Lamar Jackson returned from a lengthy hamstring injury in style, tossing four touchdowns against the Dolphins last Thursday night. This week he gets a dome matchup against a Vikings defense that’s been surprisingly soft over the past three games, allowing the eighth-most fantasy points to quarterbacks during that stretch. The Louisville product is my QB1 for the second straight week and looks fully back to form. On the other side, J.J. McCarthy was surprisingly sharp in his return from injury, putting up 19.9 fantasy points — boosted by a rushing touchdown. The Ravens’ defense will almost certainly give the rookie fits on Sunday, but his legs keep him in high-end QB2 territory with upside if game script tilts pass-heavy.

Atlanta Falcons @ Indianapolis Colts — O/U 48.5 (IND -6)

Michael Penix Jr. continues to flash deep-ball potential but remains volatile. This matchup has sneaky shootout potential, and Penix is a high-risk, high-reward QB2.
Daniel Jones is money at home and should have no issues reaching low-end QB1/high-end QB2 numbers with upside if Atlanta’s offense keeps up.

N.Y. Giants @ Chicago Bears — O/U 48.5 (CHI -3.5)

Caleb Williams is cooking. After last week’s QB1 fireworks, he now faces a soft Giants defense that’s allowed the second-most fantasy points to quarterbacks on average over the past three weeks. He’s a locked-in top-five QB again with upside.
Jaxson Dart has been steady and gutsy, and he should have to throw and most importantly run a lot to keep up with Caleb on the road.

New England Patriots @ Tampa Bay Buccaneers — O/U 48.0 (TB -2.5)

Drake Maye had his three-week streak as the overall QB1 snapped last week, “only” finishing as the QB16. If that’s his new floor, then fantasy managers are eating better than most on Thanksgiving. This week he travels to Tampa Bay — a defense that’s been stingy — but Maye has been virtually matchup-proof all season. Meanwhile, Baker Mayfield at home is usually a recipe for success. Coming off a bye week, the former Oklahoma Sooner should be rested, dialed in, and ready to deliver another serving of QB1 production.

Check out all of our Week 10 Rankings: Flex Rankings | QB Rankings | RB Rankings | WR Rankings | TE Rankings

⚖️ Mid-Range Totals (Balanced – 44 to 47)

These games could go either way — full of fantasy candy or defensive cobwebs.

Philadelphia Eagles @ Green Bay Packers — O/U 45.0 (GB -2.5)

This one feels like the mashed potatoes of the slate — reliable, hearty, and always good for you.
Jalen Hurts remains matchup-proof, and his rushing gives him elite floor and ceiling alike. He’s a top-10 play even in a tough Lambeau setting.
Jordan Love, on the other hand, has cooled since his early-season surge. He’s a middling QB2 with limited upside against Philly’s pressure even at home.

Arizona Cardinals @ Seattle Seahawks — O/U 45.5 (SEA -6.5)

Kyler Murray (foot) feels like he’s going to return any week now after barely missing last week. I’m banking on him playing, and his rushing gives him sneaky upside in a game that could quietly shoot out.
Sam Darnold, fresh off a top-five Week 9, has earned streaming trust. Seattle’s offense is rolling, and he’s a confident mid-QB2 with a safe floor.

Pittsburgh Steelers @ L.A. Chargers — O/U 44.5 (LAC -3)

Justin Herbert stays hot, coming off a QB4 finish (28.7 points). Pittsburgh’s defense is tough, but Herbert’s volume keeps him solidly in QB1 range.
Aaron Rodgers is back to managing games, not winning them in fantasy. Keep him on the bench this week.

🛑 Low-Total Games (Defensive Grind – 43 or Less)

Expect slower, grindy games — a few fantasy scares could lurk here.

Las Vegas Raiders @ Denver Broncos — O/U 42.5 (DEN -10)

A Thursday night appetizer with a side of defensive slugfest.
Bo Nix continues to play efficient football, and his legs keep him fantasy-relevant. He’s a safe QB1 against a Raiders defense allowing the fifth-most fantasy points on average to quarterbacks over their past two games.
Geno Smith comes off a surprisingly strong Week 9 (27.3 points) but faces a tough Denver secondary on the road — proceed cautiously.

Jacksonville Jaguars @ Houston Texans — O/U 38.0 (HOU -1)

This one feels like dry turkey — hard to swallow for fantasy managers.
C.J. Stroud suffered a concussion early last week against Denver, but if he plays, the matchup is decent. He’s a risky low-end QB2 if he plays.
Trevor Lawrence has been using his legs a lot more often than usual, which provides a safe floor, but the Texans defense is allowing the 11th-fewest fantasy points to quarterbacks on average over the past three weeks. Managers will have to hope he overcomes a tough Houston defense on the road to produce mid-range QB2 numbers.

Cleveland Browns @ N.Y. Jets — O/U 36.5 (NYJ -2.5)

If you start a QB in this one, you probably forgot to set your lineup.
Dillon Gabriel has been fine, albeit underwhelming, to start his rookie year and now draws a tough road matchup against the Jets. With most of New York’s studs being traded at the deadline, Gabriel could have a better time, but hopeflly you have a better option. Justin Fields, now starting for the Jets, has rushing appeal but not much else in this defensive slog.

New Orleans Saints @ Carolina Panthers — O/U 40.5 (CAR -5.5)

Bryce Young has quietly been more efficient at home and gets a beatable Saints defense. He’s a deep-league QB2 flyer.
Tyler Shough remains unplayable in fantasy — like that one weird Thanksgiving side dish no one touches.

🌙 Primetime Magic — Sunday & Monday Night

L.A. Rams @ San Francisco 49ers — O/U 50.0 (SF -3.5)

It’s another NFC West clash with fireworks potential.
Matthew Stafford is fresh off a 26.8-point week and should stay hot in this spot. Expect high-end QB2 numbers.
Brock Purdy is trending up, too; if he starts, he’s a strong QB1 at home.

Make sure to check out all of our Week 10 Fantasy Football Rankings and Analysis!

📊 Fantasy Football Week 10 Quarterback Rankings