I want to start this with Merry Christmas to all of those who celebrate and happy holidays to everyone!
We are nearing the end of the NFL regular season and that means the NFL playoffs are coming. If you were unaware, one of the good things I do is I run a playoff challenge for Ride Hard Breathe Easy. This organization does a lot of good helping to alleviate the suffering of lung cancer patients.
If you are interested in playing, please feel free to reach out to me on X @MikeReedyFF
With that said I hope you all enjoy the Holidays with family and friends and raise a cup of cheer for me. Now let us get to the Late Slate for Week 16.
Week 16 NFL DFS for the Late Slate
Quarterbacks
Josh Allen
If you’re looking to pay up, Josh Allen is the top choice this week. Over his last three games, Allen has accounted for an incredible 13 total touchdowns. While the Patriots held Kyler Murray in check last week, they allowed 11 touchdowns in the three games before that. Facing this inconsistent defense, Allen is a safe bet for at least three total touchdowns in Week 16. Lock him into your lineups with confidence.
$8,700 on DraftKings
$9,400 on FanDuel
Mac Jones
I might be taking a bold leap here, but hear me out—Jones is a sneaky play this week. He’s thrown for multiple touchdowns in two of his last three games and faces a Raiders defense in Week 16 that has allowed 300 yards or multiple passing touchdowns in six of their last seven outings. With something to play for and a favorable matchup against a defense vulnerable to the pass, Jones is an intriguing GPP option with plenty of upside.
$5,200 on DraftKings
$6,800 on FanDuel
Drake Maye
Drake Maye is a sneaky play in Week 16 as the Patriots face the Bills. Maye has posted 18 or more fantasy points in 3 of his last 4 games, showcasing his dual-threat ability to make plays through the air and on the ground. The Bills’ defense has been vulnerable to the run, giving Maye an additional path to fantasy success. With the Patriots needing to move the ball to stay competitive, Maye has the opportunity to deliver another solid performance. Consider him a GPP option this week.
$5,800 on DraftKings
$6,800 on FanDuel
Running Backs
James Cook
James Cook is an amazing start in Week 16 as the Bills take on the Patriots. New England’s defense has been a sieve against running backs, allowing the seventh most fantasy points to the position this season. Cook, currently the overall RB10 in fantasy, has been on fire, scoring 15 or more fantasy points in 4 of his last 5 games. With his explosive playmaking ability and favorable matchup, Cook is poised for another big performance. Lock him in as a high-upside RB1 this week.
$7,000 on DraftKings
$8,700 on FanDuel
Alexander Mattison
Alexander Mattison is a solid floor play in Week 16 as the Raiders face the Jaguars. Jacksonville has struggled against running backs, allowing the third-most fantasy points to the position. On average, running backs are posting 101 rushing yards and a touchdown per game against this defense. With his steady workload, Mattison is a dependable option to deliver consistent production in this favorable matchup.
$5,100 on DraftKings
$5,600 on FanDuel
Rhamondre Stevenson
Rhamondre Stevenson is an interesting play in Week 16 against the Bills. Buffalo’s defense has been a favorable matchup for running backs, allowing the second-most fantasy points to the position. On average, running backs are putting up 98 rushing yards, 50 receiving yards, and a touchdown per game against the Bills. With Stevenson’s dual-threat ability and consistent involvement in the Patriots’ offense, he’s poised for a big week.
$5,900 on DraftKings
$6,500 on FanDuel
Wide Receivers
Jaxon Smith-Njigba
The Vikings have been a goldmine for opposing wide receivers, allowing the most fantasy points to the position this season. In Week 16, the Seahawks take on Minnesota, and Jaxon Smith-Njigba (JSN) is set to shine. JSN leads the Seahawks with a 23% target share and has racked up 114 targets on the year. Notably, 20 different wide receivers have posted double-digit fantasy points against the Vikings this season. With his consistent target volume and production, JSN is poised to become number 21 this week. Start him with confidence!
$6,000 on DraftKings
$7,900 on FanDuel
Khalil Shakir
Khalil Shakir is a strong play in Week 16 as the Bills take on the Patriots. Shakir has been a consistent contributor, seeing 7 or more targets in 8 straight games while commanding a 20% target share. His incredible 81% catch rate—the highest on the Bills—shows just how reliable he’s been. With the Patriots struggling to defend the slot, Shakir is primed for another productive outing. Being a Patriots fan I hate this!
$5,900 on DraftKings
$6,600 on FanDuel
Brian Thomas Jr.
Brian Thomas Jr. is a great play in Week 16 as he faces the Raiders. Over the last three games, all with Mac Jones under center, Thomas has been a target magnet with double-digit targets in each game and a massive 33% target share during that span. The volume alone makes him a high-upside option, against the Raiders. BTJ all the way!
$6,300 on DraftKings
$7,300 on FanDuel
Jakobi Meyers
Jakobi Meyers is a solid play in Week 16 as the Raiders take on the Jaguars. Jacksonville’s defense has struggled against wide receivers, allowing the third-most fantasy points to the position. Meyers boasts a 20% target share and averages an impressive 11.3 yards per reception. With the Jaguars giving up 13 receptions, 190 yards, and a touchdown per game to wideouts, Meyers is in a great spot to deliver a productive outing. Lock him into your lineups as a dependable option this week.
$5,800 on DraftKings
$6,700 on FanDuel
Tight Ends
Brock Bowers
Bowers’ production has dipped over the past two weeks, largely due to a decrease in target volume. However, Week 16 brings a favorable matchup against the Jaguars, who allow the eighth-most fantasy points to opposing tight ends. With this opportunity on the horizon, Bowers is in a prime spot for a bounce-back performance. Keep him in your lineup and expect better results this week.
$6,500 on DraftKings
$7,700 on FanDuel
Brenton Strange
The Jaguars and Raiders face off this week, presenting a promising matchup for tight ends. The Raiders allow the fourth-most fantasy points to opposing tight ends, making this an ideal opportunity. In Week 15, Brenton Strange was heavily involved, earning 12 targets and converting them into 11 receptions for 73 yards—a 26% target share, the second-highest on the team. With Mac Jones back under center, Strange is poised to deliver once again. Don’t hesitate to plug him into your lineup this week!
$3,500 on DraftKings
$5,200 on FanDuel
Defense
Jaguars
The Jaguars’ defense is a strong play in Week 16 against the Raiders. Las Vegas has been a prime matchup for opposing defenses, allowing the third-most fantasy points to the position this season. With turnover-prone play and a struggling offensive line, the Raiders present plenty of opportunities for sacks, interceptions, and potential big plays. Start the Jaguars’ defense with confidence this week.
$2,900 on DraftKings
$3,600 on FanDuel
Make sure to check out all of our Week 16 Fantasy Football Rankings and Analysis!